Meiotic spindle position and second polar body orientation enable the prediction of embryonic developmental potential and embryo euploidy

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Meiotic spindle, spindle checkpoint and embryonic aneuploidy.

In mitosis, a spindle checkpoint plays important roles at the metaphase-anaphase transition to ensure the formation of a bipolar spindle, the completion of connecting chromosomes to microtubules and the alignment of all chromosomes at the spindle equator before initiation of anaphase. Components of the spindle checkpoint were first identified through genetic screens in budding yeast and some ch...

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ژورنال

عنوان ژورنال: Fertility and Sterility

سال: 2018

ISSN: 0015-0282

DOI: 10.1016/j.fertnstert.2018.07.648